Ezurpimtrostat (hydrochloride)

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].

Product Specifications

CAS Number

[1914148-73-4]

Product Name Alternative

GNS561 (hydrochloride)

UNSPSC

12352005

Target

Palmitoyl Protein Thioesterase (PPT)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ezurpimtrostat-hydrochloride.html

Purity

99.29

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(NC1CCN(C2=CC(NCC3=CC=C(Cl)C=C3)=NC4=CC=CC=C24)CC1)(C)C.[H]Cl

Molecular Formula

C25H32Cl2N4

Molecular Weight

459.45

References & Citations

[1]Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1.