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ART899

Product Specifications

CAS Number

2607139-85-3

SKU

C01966-5mg

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Additionnal Information

ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells.

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