Tinlorafenib
Product Specifications
CAS Number
2573781-75-4
Synonyms
PF-07284890; ARRY-461
SKU
C01799-1mg
Target
Raf
Applications
MAPK
Additionnal Information
Tinlorafenib (PF-07284890, ARRY-461) is a potent, brain-penetrant inhibitor of BRAF targeting V600E/V600K mutations with IC50 values of 4.25 nM and 2.7 nM, respectively. It also effectively inhibits ERK phosphorylation and represents a new class of selective BRAF inhibitors for brain tumors.
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