Elsubrutinib
Product Specifications
CAS Number
1643570-24-4
Synonyms
ABBV-105
SKU
C01770-1mg
Target
BTK
Applications
Protein Tyrosine Kinase
Additionnal Information
Elsubrutinib (ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in models of rheumatoid arthritis and lupus.
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