EN450
Product Specifications
CAS Number
793719-01-4
SKU
C01743-5mg
Target
NF-κB
Applications
NF-κB
Additionnal Information
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. It interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D that induces the ternary complex formation between UBE2D and NFKB1. It exhibits anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.
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