What is the catalog number for GNE-7883?

The catalog number for GNE-7883 is C01738.

What sizes are available for GNE-7883?

GNE-7883 is available in the following size(s): 1 mg, 5 mg, 25 mg, 100 mg.

How many pack sizes does GNE-7883 come in?

GNE-7883 is available in 4 different pack sizes.

Is GNE-7883 in stock?

GNE-7883 is currently made to order / not held in immediate stock. Contact us for lead time.

GNE-7883

Product Specifications

CAS Number

2648450-42-2

SKU

C01738-1mg

Target

YAP

Applications

Hippo

Additionnal Information

GNE-7883 is a potent and allosteric small-molecule inhibitor of pan-TEAD, that allosterically blocks the interactions between YAP/TAZ and all human TEAD paralogs through binding to the TEAD lipid pocket. It effectively reduces chromatin accessibility at TEAD motifs, suppresses cell proliferation in a variety of cell line models and achieves strong antitumor efficacy in vivo. Furthermore, it effectively overcomes KRAS G12C inhibitor resistance.