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Tefinostat (CHR-2845)

Product Specifications

CAS Number

914382-60-8

SKU

C01730-1mg

Target

HDAC

Applications

DNA Damage/DNA Repair

Additionnal Information

Tefinostat (CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC) . Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.

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