Tefinostat (CHR-2845)
Product Specifications
CAS Number
914382-60-8
SKU
C01730-1mg
Target
HDAC
Applications
DNA Damage/DNA Repair
Additionnal Information
Tefinostat (CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC) . Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.
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