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I-138

Product Specifications

CAS Number

2098211-50-6

SKU

C01695-5mg

Target

DUB

Applications

Ubiquitin

Additionnal Information

I-138 is an orally active, potent reversible inhibitor of USP1-UAF1 with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells.

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