LY 345899
Product Specifications
CAS Number
10538-99-5
SKU
C01613-5mg
Target
Others
Applications
Others
Additionnal Information
LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models.
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