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LY 345899

Product Specifications

CAS Number

10538-99-5

SKU

C01613-5mg

Target

Others

Applications

Others

Additionnal Information

LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models.

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