MLT-985
MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies[1][2].
Product Specifications
CAS Number
1832576-25-6
UNSPSC
12352005
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mlt-985.html
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CO[C@H](C1=C(NC(NC2=CN=C(N3N=CC=N3)C(Cl)=C2)=O)C=NC4=CC(Cl)=NN14)C
Molecular Formula
C17H15Cl2N9O2
Molecular Weight
448.27
References & Citations
[1]Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63 (23) :14594-14608.|[2]Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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