GSK215

Product Specifications

CAS Number

2743427-26-9

SKU

C01481-5mg

Target

FAK

Applications

Protein Tyrosine Kinase

Smiles

CNC (=O) C1=C (NC2=CC (=NC=C2C (F) (F) F) NC3=C (OC) C=C (C=C3) N4CCN (CC4) CC (=O) NC (C (=O) N5CC (O) CC5C (=O) NC (C) C6=CC=C (C=C6) C7=C (C) N=CS7) C (C) (C) C) C=CC=C1

Additionnal Information

GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader, which exerts FAK degradation in A549 non-small-cell lung cancer cells with DC50 of 1.3 nM by a strong time-dependence way and maximal degradation (Dmax) near the limit of the assay quantification (Dmax 99%) .