Emvododstat (PTC299)
Product Specifications
CAS Number
1256565-36-2
SKU
C01464-5mg
Target
Dehydrogenase
Applications
Metabolism
Smiles
COC1=CC=C (C=C1) C2N (CCC3=C2[NH]C4=C3C=C (Cl) C=C4) C (=O) OC5=CC=C (Cl) C=C5
Additionnal Information
Emvododstat (PTC299), a post-transcriptional inhibitor of pathogenic VEGF and dihydroorotate dehydrogenase (DHODH), inhibits VEGFA mRNA translation and abnormal cell proliferation. In HeLa cells PTC299 inhibits hypoxia-induced VEGFA protein production with an EC50 of 1.64 nM.
Storage Conditions
3 years -20°C powder
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