UNC6934
Product Specifications
CAS Number
2561494-77-5
SKU
C01452-5mg
Target
NSD
Applications
Epigenetics
Smiles
O=C1COC2=C (N1) C=CC (=C2) C (=O) N (CC3=CC=C (C=C3) C (=O) NC4=CC=NC=N4) C5CC5
Additionnal Information
UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
Storage Conditions
3 years -20°C powder
Available Sizes
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