O-Demethyl-Gefitinib
Product Specifications
CAS Number
847949-49-9
SKU
C01394-5mg
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
OC1=CC2=C (C=C1OCCCN3CCOCC3) C (=NC=N2) NC4=CC (=C (F) C=C4) Cl
Additionnal Information
O-Desmethyl gefitinib, a major active metabolite of gefitinib, is a potent EGFR (ErbB1/HER1) inhibitor, inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM, respectively.
Storage Conditions
3 years -20°C powder
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