Gefurulimab (Anti-C5 & Serum Albumin)

Gefurulimab is a humanized bispecific VHH antibody targeting both terminal complement protein C5 and albumin, with potential anti-inflammatory and immunomodulatory effects. It inhibits the terminal complement pathway by blocking the cleavage of C5 into C5a and C5b, reducing complement-mediated inflammation and cell lysis. By binding to albumin, gefurulimab increases its half-life, offering a potent and selective inhibition of terminal complement activity, including in the rare R885H C5 polymorphism. MW: 28.99 KD.