TDP-665759
TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM) . TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
787632-66-0
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tdp-665759.html
Smiles
O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O
Molecular Formula
C31H34Cl2IN5O2
Molecular Weight
706.44
References & Citations
[1]Koblish HK, et al. Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo. Mol Cancer Ther. 2006 Jan;5 (1) :160-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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