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ML133 (hydrochloride)

ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

Product Specifications

CAS Number

1222781-70-5

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335, H400

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ml133-hydrochloride.html

Purity

99.82

Solubility

DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl

Molecular Formula

C19H20ClNO

Molecular Weight

313.82

Precautions

H302, H315, H318, H335, H400

References & Citations

[1]Wang HR, et al. Selective inhibition of the K (ir) 2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6 (8) :845-56.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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