ML133 (hydrochloride)
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].
Product Specifications
CAS Number
1222781-70-5
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335, H400
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ml133-hydrochloride.html
Purity
99.82
Solubility
DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl
Molecular Formula
C19H20ClNO
Molecular Weight
313.82
Precautions
H302, H315, H318, H335, H400
References & Citations
[1]Wang HR, et al. Selective inhibition of the K (ir) 2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6 (8) :845-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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