PF-06273340
PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan Trk inhibitor[1].
Product Specifications
CAS Number
1402438-74-7
UNSPSC
12352005
Hazard Statement
H302
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-06273340.html
Purity
98.8
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1=CC(C(C2=CN(C(C)(C)CO)C3=NC(N)=NC=C32)=O)=CN=C1)CC4=NC=C(Cl)C=C4
Molecular Formula
C23H22ClN7O3
Molecular Weight
479.92
Precautions
H302
References & Citations
[1]Skerratt SE, et al. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Trk
Available Sizes
Frequently Asked Questions
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