Methylprednisolone aceponate

Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders[1][2][3].

Product Specifications

CAS Number

[86401-95-8]

Product Name Alternative

ZK 91588; MPA

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/methylprednisolone-aceponate.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C([C@@H](C)C3)=CC(C=C4)=O)C)([H])[C@@H](O)C2)([H])CC1)C)OC(CC)=O)=O)=O

Molecular Formula

C27H36O7

Molecular Weight

472.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders -- a clinical update. Int J Clin Pract. 2006 Jan;60 (1) :85-92. |[2]H.J. Zentel, et al. Preclinical evaluation of a new topical corticosteroid methylprednisolone aceponate. 1994. 3 (s1), S32-S38. |[3]Schäcke H, et al. Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol. 2009 Oct;158 (4) :1088-103.