Josamycin (hydrochloride)
Josamycin (EN-141) hydrochloride is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin hydrochloride is 5.5 nM[1][2].
Product Specifications
CAS Number
[11033-19-5]
Product Name Alternative
EN-141 (hydrochloride)
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/josamycin-hydrochloride.html
Smiles
C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(O1)=O)OC(C)=O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@](O)([C@H]([C@@H](O3)C)OC(CC(C)C)=O)C)N(C)C)O)CC=O)C)O.Cl
Molecular Formula
C42H70ClNO15
Molecular Weight
864.46
References & Citations
[1]Lovmar M, et al. Kinetics of macrolide action: the Josamycin and erythromycin cases. J Biol Chem. 2004 Dec 17;279 (51) :53506-15.|[2]Osono T, et al. Pharmacokinetics of macrolides, lincosamides and streptogramins. J Antimicrob Chemother. 1985 Jul;16 Suppl A:151-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Macrolide
Curated Selection
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