Pimonidazole

Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

Product Specifications

CAS Number

[70132-50-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pimonidazole.html

Purity

99.32

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 1 mg/mL (ultrasonic)

Smiles

OC(CN1C=CN=C1[N+]([O-])=O)CN2CCCCC2

Molecular Formula

C11H18N4O3

Molecular Weight

254.29

Precautions

H302

References & Citations

[1]Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71 (2) :270-7.|[2]Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11 (8) :e0161639.