NBC19

NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC50s of 80 nM and 850 nM, respectively[1].

Product Specifications

CAS Number

[2068818-75-5]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nbc19.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C)C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4

Molecular Formula

C24H26BCl3N2O2

Molecular Weight

491.65

References & Citations

[1]Redondo-Castro E, et al. Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci Rep. 2018 Apr 4;8 (1) :5667.