(2R,3S) -E1R
(2R,3S) -E1R (Compound 2c) is an enantiomer of E1R. (2R,3S) -E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].
Product Specifications
CAS Number
[1424832-60-9]
Product Name Alternative
MK-0869; MK-869; L-754030
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2r-3s-e1r.html
Purity
98.84
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N)CN1[C@H](C)[C@H](C2=CC=CC=C2)CC1=O
Molecular Formula
C13H16N2O2
Molecular Weight
232.28
References & Citations
[1]Veinberg G, et al. Synthesis and biological evaluation of 2- (5-methyl-4-phenyl-2-oxopyrrolidin-1-yl) -acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21 (10) :2764-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor
Available Sizes
Curated Selection
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