Sotorasib
Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC) [1][2][3][4][5][6].
Product Specifications
CAS Number
2296729-00-3
Product Name Alternative
AMG-510
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG-510.html
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic; adjust pH to 11 with NaOH)
Smiles
O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1
Molecular Formula
C30H30F2N6O3
Molecular Weight
560.59
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
K-Ras
Available Sizes
Frequently Asked Questions
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