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TCEP-d12 (hydrochloride)

TCEP-d12 (hydrochloride) (Tris (2- carboxyethyl) phosphine hydrochloride-d12) is deuterium labeled TCEP (hydrochloride) . TCEP hydrochloride (Tris (2-carboxyethyl) phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry[1][2][3][4][5].

Product Specifications

CAS Number

1189959-10-1

Product Name Alternative

Tris (2-​carboxyethyl) ​phosphine hydrochloride-d12

UNSPSC

12352211

Target

Isotope-Labeled Compounds

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Smiles

OC(C([2H])([2H])C([2H])([2H])P(C([2H])([2H])C([2H])([2H])C(O)=O)C([2H])([2H])C([2H])([2H])C(O)=O)=O.Cl

Molecular Formula

C9H4D12ClO6P

Molecular Weight

298.72

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Han JC, Han GY. A procedure for quantitative determination of tris (2-carboxyethyl) phosphine, an odorless reducing agent more stable and effective than dithiothreitol. Anal Biochem. 1994;220 (1) :5-10. |[3]Dieguez-Acuña FJ, et al. Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris (2-carboxyethyl) phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents. Toxicol In Vitro. 2000 Feb;14 (1) :7-16.|[4]Duchardt F, et al. A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J Biol Chem. 2009 Dec 25;284 (52) :36099-108.|[5]Sequeira MA, et al. Modulating amyloid fibrillation in a minimalist model peptide by intermolecular disulfide chemical reduction. Phys Chem Chem Phys. 2019 Jun 5;21 (22) :11916-11923.|[6]Wu R, et al. Effects of Small Molecules on DNA Adsorption by Gold Nanoparticles and a Case Study of Tris (2-carboxyethyl) phosphine (TCEP) . Langmuir. 2019 Oct 15;35 (41) :13461-13468.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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