CBL0137
CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-κB and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis[1].
Product Specifications
CAS Number
1197996-80-7
Product Name Alternative
Curaxin 137; CBL-C137
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Acetyltransferase; MDM-2/p53; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CBL-0137.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Available Sizes
Frequently Asked Questions
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