TC-S 7009
Product Specifications
UNSPSC Description
TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2].
Target Antigen
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tc-s-7009.html
Purity
99.64
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1
Molecular Weight
308.65
References & Citations
[1]Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013 Apr;9(4):271-6.|[2]Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018 Feb 9;8(1):2709.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18371/TC-S-7009-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18371/TC-S-7009-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1422955-31-4
Available Sizes
Curated Selection
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