IZTZ-1
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].
Product Specifications
CAS Number
2636771-45-2
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iztz-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC=C(C3=C(C4=CC=C(N5CCN(C)CC5)C=C4)N=C(C6=NC7=CC=CC=C7S6)N3)C=C2)CC1
Molecular Formula
C32H35N7S
Molecular Weight
549.73
References & Citations
[1]Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB1850-100 1x 100 µL
PD-L2 / PDCD1LG2 / CD273 (PDL2/1850), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TRC-A604620-500MG 500 mg
6-Amino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyrimidinedione
Sign In for Pricing
View Details 
BNC942052-500 1x 500 µL
TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) (VEGI/2052R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
E-EL-H2059-01 24 Tests
Human ProGRP (Pro-Gastrin Releasing Peptide) ELISA Kit
Sign In for Pricing
View Details