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Neutrophil elastase inhibitor 5

Product Specifications

UNSPSC Description

Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases[1].

Target Antigen

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/neutrophil-elastase-inhibitor-5.html

Solubility

DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

OC([C@H](C1=CC=CC=C1)NC(C2=NC=CC=C2/N=N/C3=C(C=CC=C4)C4=CC=C3O)=O)=O

Molecular Weight

426.42

References & Citations

[1]Hwang TL, et al. Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors. Bioorg Med Chem Lett. 2023 Nov 7;97:129544

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-155414/Neutrophil-elastase-inhibitor-5-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-155414/Neutrophil-elastase-inhibitor-5-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

3020696-44-7

Available Sizes

Curated Selection

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