Clomiphene (citrate)

Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment[1][2][3].

Product Specifications

CAS Number

[50-41-9]

Product Name Alternative

Clomifene citrate

UNSPSC

12352005

Hazard Statement

H361

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clomiphene-citrate.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O

Molecular Formula

C32H36ClNO8

Molecular Weight

598.08

Precautions

H361

References & Citations

[1]Jiann B P, et al. Effect of clomiphene on Ca2+ movement in human prostate cancer cells [J]. Life Sciences, 2002, 70 (26) : 3167-3178.|[2]London S N, et al. Clomiphene citrate-induced perturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes in vivo and in vitro [J]. Fertility and sterility, 2000, 73 (3) : 620-626.|[3]Akintoye O O, et al. Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway [J]. Life Sciences, 2023, 324: 121737.