MMP-2/MMP-9-IN-1

MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer[1].

Product Specifications

CAS Number

[193807-58-8]

Product Name Alternative

Tyrphostin B66; AG 528

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmp-2-mmp-9-in-1.html

Purity

99.25

Solubility

10 mM in DMSO

Smiles

OC([C@@H](CC1=CC=CC=C1)NS(C2=CC=C(C3=CC=CC=C3)C=C2)(=O)=O)=O

Molecular Formula

C21H19NO4S

Molecular Weight

381.44

References & Citations

[1]Y Tamura, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2) : N-sulfonylamino acid derivatives. J Med Chem. 1998 Feb 12;41 (4) :640-9.