MMP-2/MMP-9-IN-1
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer[1].
Product Specifications
CAS Number
[193807-58-8]
Product Name Alternative
Tyrphostin B66; AG 528
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmp-2-mmp-9-in-1.html
Purity
99.25
Solubility
10 mM in DMSO
Smiles
OC([C@@H](CC1=CC=CC=C1)NS(C2=CC=C(C3=CC=CC=C3)C=C2)(=O)=O)=O
Molecular Formula
C21H19NO4S
Molecular Weight
381.44
References & Citations
[1]Y Tamura, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2) : N-sulfonylamino acid derivatives. J Med Chem. 1998 Feb 12;41 (4) :640-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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