PCSK9-IN-28
Product Specifications
UNSPSC Description
PCSK9-IN-28 (Compound C11) is a PCSK9 inhibitor that can be isolated from Euphorbia esula. By binding to HNF1α, PCSK9-IN-28 inhibits PCSK9 transcription by binding to HNF1α and affecting its nuclear distribution, thereby enhancing LDLR and promoting LDL uptake. PCSK9-IN-28 exhibits significant lipid-lowering activity in the high-fat diet (HFD) mouse model and can be used in the study of hyperlipidemia[1].
Target Antigen
PCSK9
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-28.html
Smiles
C=C([C@@H]([C@]1([C@H]([C@H](C[C@@]1(C2=O)OC(C)=O)C)OC(C)=O)[H])OC(C)=O)[C@@H](CC(C(C)(/C=C/[C@H]2C)C)=O)OC(C)=O
Molecular Weight
534.60
References & Citations
[1]Chen T, et al. Novel Jatrophane Diterpenoids from Euphorbia esul a Promotes Lipid Clearance by Transcriptional Regulation of PCSK9[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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