Huperzine B

Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease[1][2].

Product Specifications

CAS Number

[103548-82-9]

UNSPSC

12352005

Hazard Statement

H300, H310, H330

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/huperzine-b.html

Purity

98.73

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=C[C@]2([H])[C@]3([H])[C@](C(C=CC4=O)=C(N4)C2)(NCCC3)C1

Molecular Formula

C16H20N2O

Molecular Weight

256.34

Precautions

H300, H310, H330

References & Citations

[1]Zhang HY, et al. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett. 2000 Sep 29;292 (1) :41-4.|[2]He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg Med Chem. 2007 Feb 1;15 (3) :1394-408.