BIO-acetoxime

BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.

Product Specifications

CAS Number

[667463-85-6]

Product Name Alternative

BIA

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Apoptosis; GSK-3; HSV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BIO-acetoxime.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 14 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OC(C)=O

Molecular Formula

C18H12BrN3O3

Molecular Weight

398.21

Precautions

H302, H410

References & Citations

[1]Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.|[2]Hsu MJ, et al. Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol. 2013 Jun;158 (6) :1287-96.|[3]Aourz N, et al. Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy. ACS Chem Neurosci. 2018 Nov 6.