SETDB1-TTD-IN-1

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive ligand of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a Kd of 88 nM. SETDB1-TTD-IN-1 increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD[1][2].

Product Specifications

CAS Number

[2755823-12-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/setdb1-ttd-in-1.html

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CN1C[C@@H](C2=CC=C(OCC3=CC=CC=C3)C=C2)C[C@@H](NC4=NC5=C(C(N4CC=C)=O)NC=C5)C1

Molecular Formula

C28H31N5O2

Molecular Weight

469.58

Precautions

H302, H315, H319

References & Citations

[1]Guo Y, et, al. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew Chem Int Ed Engl. 2021 Apr 12;60 (16) :8760-8765.|[2]Uguen M, et, al. SETDB1 Triple Tudor Domain Ligand, (R, R) -59, Promotes Methylation of Akt1 in Cells. ACS Chem Biol. 2023 Aug 18;18 (8) :1846-1853.