S100 Rabbit mAb IHC Kit
Product Specifications
Background
S100 comprises 19 members of Ca2+ binding proteins with low molecular weight between 9kDa to 13kDa. The S100 falmily proteins have been implicated to regulate protein phosphorylation, cell proliferation and differentiation in the Ca2+-dependent way. S100B is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. It is a useful marker for the identification of melanoma and various nervous system tumors.
Synonyms
Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100B
Gene Name
S100B
Gene ID
6285
Swiss Prot
P04271
Reactivity
Human; Mouse; (predicted: Rat)
Immunogen
A synthetic peptide corresponding to the amino acid region 1 - 50 of the human S100 protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can specifically recognize human S100 protein, including S100 alpha and S100 beta proteins.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Nuclear, Cytoplasmic
Protein Name
S100
Available Sizes
Curated Selection
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