P53 Rabbit mAb IHC Kit
Product Specifications
Background
P53 is a tumor suppressor gene located on chromosome 17. The mutation of p53 gene will change its spatial conformation and turn into oncogene, and then lose the regulation of cell growth, apoptosis and DNA repair. The mutation or deletion of p53 gene is the cause of many tumors. Compared with the wild-type protein, the mutant p53 protein has a longer half-life, so it is easier to detect by immunohistochemistry. The p53 mutant protein is expressed in many kinds of tumors, such as breast cancer, gastrointestinal cancer, hepatocellular carcinoma and respiratory tract tumor. It is mainly used for the study of various tumors and can be used as an indicator of tumor prognosis.
Synonyms
Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; tumor antigen p55; Tumor protein 53; Tumor protein p53; Tumor suppressor p53
Gene Name
TP53 P53
Gene ID
7157
Swiss Prot
P04637
Reactivity
Human
Immunogen
A synthetic peptide corresponding to the amino acid region 250 - 393 of the human P53 protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can recognize human wild type and mutant P53 protein.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Nuclear
Protein Name
P53
Available Sizes
Frequently Asked Questions
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