Estrogen Receptor α Rabbit mAb IHC Kit
Product Specifications
Background
Estrogen receptor (ER) is a protein with 553 amino acids which belongs to the steroid receptor superfamily of nuclear receptors. It has three domains, including the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids on growth, differentiation and function in several tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems. Clinical data show that ER in breast cancer is an important parameter for predicting the prognosis of breast cancer and endocrine therapy, so ER/PR is one of the routine examination items for breast cancer patients.
Synonyms
ESR1 ESR NR3A1
Gene Name
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene ID
2099
Swiss Prot
P03372
Reactivity
Human
Immunogen
A synthetic peptide corresponding to the amino acid region 450 - 595 of the human Estrogen Receptor α protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can recognize human Estrogen receptor protein.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Nuclear
Protein Name
Estrogen Receptor α
Available Sizes
Frequently Asked Questions
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