BRCA1 Rabbit mAb IHC Kit
Product Specifications
Background
BRCA1 (Breast Cancer 1) protein is a tumor suppressor protein encoded by the BRCA1 gene, primarily involved in DNA damage repair, cell cycle regulation, and genome stability maintenance. BRCA1 plays a crucial role in homologous recombination repair (HRR), and its deficiency can lead to the accumulation of genetic mutations, thereby increasing the risk of cancer. BRCA1 has significant pathological importance in the occurrence, progression, and personalized treatment of various cancers, including breast and ovarian cancer.
Synonyms
RNF53, BRCA1, Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1
Gene Name
BRCA1 RNF53
Gene ID
672
Swiss Prot
P38398
Reactivity
Human
Immunogen
A synthetic peptide corresponding to the amino acid region 450 - 550 of the human BRCA1 protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can recognize human BRCA1 protein.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Nuclear, Cytoplasmic
Protein Name
BRCA1
Available Sizes
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