Actin, muscle specific (MSA) Rabbit mAb IHC Kit
Product Specifications
Background
Actin is a highly conserved cytoskeletal protein, which contains 6 isoformes, of which 4 are muscle tissue specific: α-skeletal muscle actin, α-cardiac muscle actin, α-smooth muscle actin, γ-Smooth muscle actin. Muscle actin is expressed in skeletal muscle, cardiac and smooth muscle, and muscle derived tumors such as leiomyoma and rhabdomyosarcoma. It is usually not expressed in endothelial cells, connective tissue, melanoma, lymphoma and non myogenic sarcoma.
Synonyms
Actin, alpha cardiac muscle 1; Alpha-cardiac actin; Actin, alpha skeletal muscle; Alpha-actin-1; Actin, gamma-enteric smooth muscle; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin
Gene Name
ACTC1/ACTA1/ACTG2
Gene ID
59; 70; 58; 72
Swiss Prot
P68032; P68133; P63267; P62736
Reactivity
Human; Mouse (predicted: Rat; Bovin; Pig; Chick)
Immunogen
A synthetic peptide corresponding to the amino acid region 1 - 100 of the human actin protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can specifically recognize proteins from smooth muscle, myocardium and skeletal muscle α actin and smooth muscle derived γ actin, and β actin or non smooth muscle derived γ actin does not respond.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Cytoplasmic
Protein Name
Actin, muscle specific
Available Sizes
Frequently Asked Questions
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