PVHL Mouse mAb IHC Kit

PVHL (Von Hippel-Lindau protein), with a molecular weight of approximately 30 kDa, is a tumor suppressor protein encoded by the VHL gene. Its primary function is to regulate intracellular protein degradation, particularly in relation to the hypoxia-inducible factor (HIF) . pVHL is a crucial tumor suppressor that influences angiogenesis, metabolism, and tumor growth by modulating HIF degradation. Mutations in the VHL gene are the main driving factor of clear cell renal cell carcinoma (ccRCC) and are closely associated with hereditary diseases such as Von Hippel-Lindau disease. Pathological detection of pVHL and related targeted therapies play a significant role in cancer diagnosis and treatment.