Cytokeratin 8 Mouse mAb IHC Kit
Product Specifications
Background
Cytokeratin 8 (CK8) is a member of the type II family of cytokeratins with a molecular weight of 53kDa which plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. It generally exists in monolayer and pseudostratified epithelium, and is expressed in glandular epithelium, transitional epithelium and hepatocytes. It is absent in squamous cell carcinomas. CK8 dimerizes with CK18 to form an intermediate filament in simple single-layered epithelial cells. CK8/18 expression patterns are useful for classification of tumors of unknown origin and poorly differentiated carcinomas.
Synonyms
CARD2, CK 8, CK-8, CK8, CYK8, CYKER, Cytokeratin endo A, CytokeRatin-8, DreK8, EndoA, K2C8, K2C8_HUMAN, K8, KeRatin 8, KeRatin type II cytoskeletal 8, KeRatin, type II cytoskeletal 8, KeRatin-8, KO, Krt 2. 8, KRT8, MGC118110, MGC174782, MGC53564, MGC85764, sb:cb186, Type-II keRatin Kb8
Gene Name
KRT8
Gene ID
3856
Swiss Prot
P05787
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide corresponding to the amino acid region 400 - 483 of the human Cytokeratin 8 protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can specifically recognize human CK8 protein, and shows no cross reaction with CK1, 4, 5, 6, 7, 10, 15, 16, 17, 18, 20.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Cytoplasmic, Membranous
Protein Name
Cytokeratin 8
Available Sizes
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