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Cytokeratin 19 Mouse mAb IHC Kit

Product Specifications

Background

CK19 is a cytokeratin with a molecular weight of 40 kDa. It is mainly expressed in monolayer epithelium and ductal epithelium, and can be detected in the basal layer of squamous epithelium and epidermis. It is a good marker of epithelial differentiation. It is mainly used for the diagnosis of adenocarcinoma. Hepatocytes do not express CK19, but bile duct epithelium does, so it can be used to distinguish hepatocellular carcinoma from intrahepatic cholangiocarcinoma and metastatic adenocarcinoma. CK19 is partially or weakly expressed in normal thyroid tissue, follicular adenoma, nodular goiter and papillary hyperplasia, but it can be diffusely and strongly expressed in thyroid papillary carcinoma.

Synonyms

40 kDa keRatin intermediate filament, CK 19, CK-19, CK19, Cytokeratin 19, CytokeRatin-19, K19, K1C19_HUMAN, K1CS, KeRatin 19, KeRatin type I 40 kD, KeRatin type I 40kD, KeRatin type I cytoskeletal 19, KeRatin, type I cytoskeletal 19, KeRatin, type I, 40 kd, KeRatin-19, KRT19, MGC15366

Gene Name

KRT19

Gene ID

3880

Swiss Prot

P08727

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the amino acid region 300 - 400 of the human Cytokeratin 19 protein.

Applications

Immunohistochemistry (IHC)

Dilution

It has been optimized for direct use, requiring no further dilution.

Specificity

The antibody can specifically recognize human CK19 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 10, 13, 14, 15, 17, 18, 20.

Formulation

The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.

Subcellular Location

Cytoplasmic, Membranous

Protein Name

Cytokeratin 19

Available Sizes

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