Cytokeratin 1 Mouse mAb IHC Kit

Product Specifications

Background

Cytokeratin 1 is a 68 kDa protein with the structure of alpha-helical coiled-coil dimers and it is highly expressed in keratinized squamous epithelium. CK1 forms a complete cellular support network system, provides mechanical strength support for cells, and participates in cell differentiation and intracellular information transmission. Diseases associated with CK1 include Ichthyosis, Epidermolytic Hyperkeratosis and Palmoplantar Keratoderma, Nonepidermolytic.

Synonyms

67 kDa cytokeRatin, CK-1, CK1, CytokeRatin-1, CytokeRatin1, EHK, EHK1, Epidermolytic hyperkeRatosis 1, EPPK, Hair alpha protein, K1, K2C1_HUMAN, KeRatin, KeRatin type II cytoskeletal 1, KeRatin-1, KeRatin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keRatin Kb1, Type-II keRatin Kb1

Gene Name

KRT1

Gene ID

3848

Swiss Prot

P04264

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the amino acid region 200 - 300 of the human Cytokeratin 1 protein.

Applications

Immunohistochemistry (IHC)

Dilution

It has been optimized for direct use, requiring no further dilution.

Specificity

The antibody can specifically recognize human CK1 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels only skin epidermal cells, whereas squamous or glandular epithelium cells are not labeled.