Estrogen Receptor α (AB1445) Rabbit mAb (Ready to Use)

Estrogen receptor (ER) is a protein with 553 amino acids which belongs to the steroid receptor superfamily of nuclear receptors. It has three domains, including the central DNA- binding domain, the hormone- binding domain at the C- terminal, and the transcription- activating domain at the N- terminal. ER mediates regulatory functions of female sex steroids on growth, differentiation and function in several tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems. Clinical data show that ER in breast cancer is an important parameter for predicting the prognosis of breast cancer and endocrine therapy, so ER/PR is one of the routine examination items for breast cancer patients.