Lamin A/C (phospho Ser392) (AB2361) mouse mAb
Product Specifications
Background
Lamin A/C (LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Synonyms
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32) ]
Gene Name
LMNA LMN1
Gene ID
4000
Swiss Prot
P02545
Host
Mouse
Reactivity
Human; Mouse; Rat; Monkey
Immunogen
A synthesized phosphopeptide corresponding to residues surrounding Ser392 of human Lamin A/C.
Clonality
Monoclonal
Source
Monoclonal, Mouse, IgG
Applications
WB; IF; ELISA
Purification
The antibody was purified by protein G affinity chromatography.
Dilution
WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modification
Phospho S392
Storage Conditions
Store at-20°C. Avoid freeze / thaw cycles.
Specificity
This antibody detects endogenous levels of Lamin A/C (phospho Ser392) protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Protein Name
Lamin A/C
Available Sizes
Frequently Asked Questions
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