BRAT1 (AB2251) Rabbit mAb

Product Specifications

Background

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex) . The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

Synonyms

BRAT1, BAAT1, C7orf27, BRCA1-associated ATM activator 1 , BRCA1-associated protein required for ATM activation protein 1

Gene Name

BRAT1, BAAT1, C7orf27

Gene ID

221927

Swiss Prot

Q6PJG6

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein (or fragment) . This information is considered to be commercially sensitive.

Clonality

Monoclonal

Source

Monoclonal, Rabbit, IgG

Applications

WB, IF/ICC, Flow Cyt, IP

Purification

The antibody was purified by protein A affinity chromatography.

Dilution

WB, 1:1000-1:5000 | IF, 1:100-1:300 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | FC, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.